Regenerative medicine is redefining how clinics approach hair restoration. Instead of relying only on mechanical stimulation or transplants, new biologic protocols aim to repair and renew the scalp itself. The most comprehensive approach now combines Wharton’s Jelly mesenchymal stem cells (MSCs), platelet lysate (PL), and autologous fibroblasts.
1. The Foundation: Wharton’s Jelly MSCs
Wharton’s Jelly MSCs are multipotent cells derived from donated umbilical cord tissue. They’re rich in growth factors and anti-inflammatory cytokines that help reactivate dormant follicles and restore vascular flow in the scalp.
Typical dose: 20–30 million cells.
Delivery: micro-injections across thinning areas, sometimes paired with intravenous support.
Effect: improved follicle metabolism, reduced shedding, and visible thickening over several months.
2. Platelet Lysate (PL): The Cytokine Booster
Platelet lysate, sometimes written as “Lisado de Plaquetas” in treatment menus, is a plasma fraction rich in platelet-derived growth factors. Unlike standard PRP, PL is acellular and smoother to inject, allowing deeper tissue penetration and less inflammation.
In this protocol, PL is used as the carrier medium for the MSCs — feeding and amplifying the regenerative signal.
3. Autologous Fibroblast Therapy: Long-Term Structural Support
Fibroblasts are the body’s natural collagen-building cells. In this treatment, a small skin sample is taken (usually from behind the ear), cultured in a lab, and expanded into millions of new fibroblasts. After four to six weeks, these cells are injected into the scalp to rebuild the dermal matrix and strengthen the tissue surrounding each follicle.
The result is a healthier, more elastic scalp that supports stronger, thicker hair growth over time.
4. Treatment Flow
Session 1 – MSC + PL: Initial regenerative signaling and vascular activation.
Session 2 – Fibroblast (after 4–6 weeks): Structural rebuilding and collagen renewal.
Session 3 – Optional booster: Light repeat with PL or fibroblast mix to maintain effect.
5. Expected Outcomes
Reduced shedding within 3–4 weeks.
Noticeably thicker hair shafts by 2–3 months.
30–40 % overall improvement in hair density over 6 months.
Results lasting 18–24 months with maintenance.
6. Cost Range (Medellín, 2025)
| Component | Costs |
|---|---|
| Wharton’s Jelly MSCs (20 M) | ≈ 1,550 USD |
| Platelet Lysate (PL) | ≈ 80 USD |
| Fibroblast Therapy (Biopsy + 2 sessions) | ≈ 1,100 USD |
| Application Room / Physician Fees | ≈ 450 USD |
| Estimated Total | ≈ 2,600 USD |
That’s about half the U.S. cost for equivalent outcomes — and with biologic repair added in.
7. Why Add Fibroblasts and PL
Platelet lysate delivers the short-term cytokine surge that wakes up follicles, while fibroblasts provide the long-term collagen framework that sustains results.
Together with MSCs, they create a three-layer biologic repair:
MSCs: signal and modulate.
PL: feed and accelerate.
Fibroblasts: rebuild and stabilize.
This combination gives fuller, more natural results than PRP alone — and it’s especially effective for early to moderate thinning where hair still exists but density is poor.
8. Longevity and Maintenance
Results peak around six months and typically hold for 18–24 months. A brief maintenance session using PL or fibroblasts once a year helps preserve scalp quality and delay future thinning.
9. Safety and Recovery
Because all materials are biologic (either donor-screened Wharton’s Jelly or the patient’s own fibroblasts), side effects are minimal — light swelling or redness for a day or two. There’s no shedding phase, and patients can return to normal activities immediately.
10. Summary
A Hair Thickening MSC + Fibroblast + PL protocol represents the most advanced non-surgical regenerative option available today.
It combines the signaling strength of stem cells, the nutrient power of platelet lysate, and the structural rebuilding of fibroblasts — producing denser hair, healthier scalp tissue, and natural longevity.