🧬 Direct evidence for hair growth using this exact three-part protocol (MSC + PL + Fibroblast) is limited.
However, there is a growing body of adjacent scientific evidence supporting the mechanisms involved — the same cellular and biochemical pathways — in other tissues such as skin, mucosa, and connective tissue repair.
1. Platelet-Derived Growth Factors (PL / PRP)
Multiple studies, including those behind the O-Shot and PRP in facial rejuvenation, show platelet factors can:
stimulate local angiogenesis (new blood vessel growth),
increase fibroblast activity, and
enhance extracellular matrix turnover.
These biologic effects explain why platelet-based biologics often improve tissue tone, elasticity, and microvascular function — properties relevant to the scalp as well.
2. Mesenchymal Stem Cells (MSCs)
Clinical and preclinical data show that MSCs from Wharton’s Jelly or adipose tissue secrete bioactive molecules (VEGF, PDGF, HGF, IGF-I) that:
modulate inflammation,
promote new capillary growth, and
activate resident stem cells in the surrounding tissue.
These same mechanisms have improved healing and texture in skin-wound and scar-repair studies, suggesting potential benefit when applied to the scalp environment.
3. Autologous Fibroblast Therapy
Autologous fibroblast implantation has been used for over a decade in facial rejuvenation and scar remodeling.
The cultured fibroblasts produce new collagen and elastin, leading to measurable improvements in dermal thickness and firmness.
If applied to the scalp, similar dermal remodeling could theoretically enhance follicle support and local microcirculation, though formal trials are lacking.
🧠 Conservative Interpretation
Current evidence therefore supports a rationale — not a proof — for combining these biologic tools.
In plain language:
“We know these cells and growth factors regenerate skin, mucosa, and connective tissue in other parts of the body. Because the scalp shares the same microvascular and dermal structure, the same mechanisms are likely to benefit hair-bearing skin.”
This approach keeps the claim scientifically honest while recognizing the potential.